In the current standards, fasteners or connections are always designed in one plane only. The reason for this is that the design checks for shearing and suchlike can only ever be analyzed in the 2D plane. For example, the bearing resistance design is not possible for an out-of-plane failure.
Since internal forces in vy and vz can always occur in a three-dimensional calculation, it has been proven useful in practice to allow a small proportion of internal forces in the secondary direction and not to fully utilize the connection. However, if the ratio of the shear force in the secondary direction is too high, a detailed analysis with an FE simulation might be necessary.