Wind direction plays a crucial role in shaping the outcomes of Computational Fluid Dynamics (CFD) simulations and the structural design of buildings and infrastructures. It is a determining factor in assessing how wind forces interact with structures, influencing the distribution of wind pressures, and consequently, the structural responses. Understanding the impact of wind direction is essential for developing designs that can withstand varying wind forces, ensuring the safety and durability of structures. Simplified, the wind direction helps in fine-tuning CFD simulations and guiding structural design principles for optimal performance and resilience against wind-induced effects.