Answer:
Yes, it is possible.You can find the control in the design details of the respective design case in RF‑/FOUNDATION Pro.
On one hand, you can select the support load (Px, Py, Pz, Mx, or My) that should not be considered in the design. On the other hand, you can also decide if forces or moments should only be deactivated for a certain direction or for all directions.
However, it is important that the deactivation of the support load is effective for all designs of the design case. If the support load Px should only be deactivated for the design of sliding, but not for all other design, you can control this by creating two design cases.